More evidence "poppers" may damage eyesight

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Poppers (slang for various alkyl nitrite compounds) are commonly used in the gay community, for their ability to relax the anal sphincter and known psychoactive effects. Following changes to legislation in 2006, poppers' main ingredient, isobutyl nitrite, was substituted for isopropyl nitrite. Since then, there have been several reports of a new form of visual loss termed poppers maculopathy. The exact mechanism by which poppers cause damage to central photoreceptors is unknown, but there is a clear cause—effect relationship. Despite online warnings outlining the risks of poppers, the number of individuals presenting with associated visual loss is increasing. Fundoscopy findings can be very subtle, with more striking changes seen on optical coherence tomography. The relatively easy availability and widespread use of poppers is underestimated and concerning, given the propensity for permanent damage to the eyes. We would encourage both end-users and healthcare professionals to be aware of the potentially serious and irreversible damage poppers can have on vision.

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More evidence "poppers" may damage eyesight

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